Gst M1 and T1 Gene Variants Deficiency with Passive Maternal Smoking during Pregnancy May Increase Asthma Risk in Indian Children
نویسندگان
چکیده
It has been evident that Glutathione S-transferase (GST) gene deficiency may contribute to the development of asthma. Therefore, we aimed to assess the association of GSTT1 and GSTM1 deficiency with passive maternal smoking (MS) during pregnancy with asthma in north Indian children. It was a hospital based case-control study, 175 bronchial asthma cases and 175 controls, aged 1 year -15 years were recruited. Cases included were those children presenting symptoms of asthma according to EPR 2007 and excluded were subjects with other respiratory diseases. Non asthmatic children were enrolled as controls. Increased risk of asthma was found in children lacking the GST M1 (OR= 6.37, 95%CI= 1.29-31.42, p= 0.024) and GST T1 (OR= 4.84, 95%CI= 1.68-13.71, p= 0.003) gene variants whose mother’s were exposed to smoking during pregnancy. We concluded that the GST gene variants(GSTT1 and GSTM1) deficiency with passive maternal smoking during pregnancy may increase asthma risk in North Indian children.
منابع مشابه
Glutathione S transferase deficiency and passive smoking increase childhood asthma.
BACKGROUND It has been suggested that the genetically determined deficiency of glutathione S transferase (GST) enzymes involved in the detoxification of environmental tobacco smoke (ETS) components may contribute to the development of asthma. METHODS A large population of German schoolchildren (n = 3054) was genotyped for deficiencies of the GST isoforms M1 and T1. The association between GST...
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